Increase in HLA-G1 proteolytic shedding by tumor cells: a regulatory pathway controlled by NF-κB inducers

@article{Zidi2006IncreaseIH,
  title={Increase in HLA-G1 proteolytic shedding by tumor cells: a regulatory pathway controlled by NF-κB inducers},
  author={I Zidi and Christine Guillard and C{\'e}line Marcou and Ir{\`e}ne Krawice-Radanne and D{\'e}borah Sangrouber and Nathalie Rouas-Freiss and Edgardo D. Carosella and Pierre Moreau},
  journal={Cellular and Molecular Life Sciences CMLS},
  year={2006},
  volume={63},
  pages={2669-2681}
}
HLA-G is expressed by tumors, in which it contributes to the evasion of immunosurveillance. NF-κB appears to be a candidate for regulating HLA-G expression, since it is considered to be a hallmark of cancer. We investigated the role of NF-κB in modulating HLA-G expression in HLA-G-positive tumor cells, JEG-3 (choriocarcinoma), FON (melanoma), and M8-HLA-G1 (HLAG1-transfected melanoma). The treatment of tumor cells with two NF-κB inducers, tumor necrosis factor-α and phorbol 12-myristate 13… CONTINUE READING

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