Increase in Endoplasmic Reticulum Stress–Related Proteins and Genes in Adipose Tissue of Obese, Insulin-Resistant Individuals

@article{Boden2008IncreaseIE,
  title={Increase in Endoplasmic Reticulum Stress–Related Proteins and Genes in Adipose Tissue of Obese, Insulin-Resistant Individuals},
  author={Guenther Boden and Xunbao Duan and Carol J. Homko and Ezequiel J. Molina and Weiwei Song and Oscar Fernando Rojas Perez and Peter K. P. Cheung and Salim Merali},
  journal={Diabetes},
  year={2008},
  volume={57},
  pages={2438 - 2444}
}
OBJECTIVE To examine fat biopsy samples from lean insulin-sensitive and obese insulin-resistant nondiabetic individuals for evidence of endoplasmic reticulum (ER) stress. RESEARCH DESIGN AND METHODS Subcutaneous fat biopsies were obtained from the upper thighs of six lean and six obese nondiabetic subjects. Fat homogenates were used for proteomic (two-dimensional gel and MALDI-TOF/TOF), Western blot, and RT-PCR analysis. RESULTS Proteomic analysis revealed 19 differentially upregulated… CONTINUE READING
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