Increase in Candida krusei infection among patients with bone marrow transplantation and neutropenia treated prophylactically with fluconazole.

@article{Wingard1991IncreaseIC,
  title={Increase in Candida krusei infection among patients with bone marrow transplantation and neutropenia treated prophylactically with fluconazole.},
  author={John R Wingard and William G. Merz and Michael G. Rinaldi and Thomas R. Johnson and Judith E. Karp and Rein Saral},
  journal={The New England journal of medicine},
  year={1991},
  volume={325 18},
  pages={1274-7}
}
BACKGROUND In early 1990 fluconazole was introduced as a prophylactic antifungal agent after bone marrow transplantation. During the same year Candida krusei emerged as the chief candida pathogen among patients with bone marrow transplants. METHODS To determine whether there was a correlation between the introduction of fluconazole and the increased incidence of C. krusei, we conducted a retrospective study based on the medical, mycologic, and autopsy records of all adult inpatients who had… CONTINUE READING
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