Incorrect nucleotide insertion at the active site of a G:A mismatch catalyzed by DNA polymerase beta.

Abstract

Based on a recent ternary complex crystal structure of human DNA polymerase beta with a G:A mismatch in the active site, we carried out a theoretical investigation of the catalytic mechanism of incorrect nucleotide incorporation using molecular dynamics simulation, quantum mechanics, combined quantum mechanics, and molecular mechanics methods. A two-stage… (More)
DOI: 10.1073/pnas.0801257105

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