Incorporation of the Model Drug Ubidecarenone into Solid Lipid Nanoparticles

@article{Bunjes2001IncorporationOT,
  title={Incorporation of the Model Drug Ubidecarenone into Solid Lipid Nanoparticles},
  author={Heike Bunjes and Markus Drechsler and Michel Henry Jean Koch and Kirsten Westesen},
  journal={Pharmaceutical Research},
  year={2001},
  volume={18},
  pages={287-293}
}
Purpose. The impact of drug incorporation on melt-homogenized tripalmitin nanoparticles is investigated with ubidecarenone as a model drug. The dispersions are studied with respect to their drug loading capacity, localization and physical state of the drug as well as to potential changes of the nanoparticle properties due to interactions between drug and triglyceride matrix. Methods. The investigations were carried out using photon correlation spectroscopy, differential scanning calorimetry… CONTINUE READING
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