Incorporation of protein-binding kinetics and carrier-mediated membrane transport into a model of chemical kinetics in the isolated perfused rat liver.

Nonlinear processes present difficult problems in extrapolating toxicological kinetics from one dose or species to another. A model that includes the details of these processes will aid in identifying those conditions under which a linear extrapolation is not valid. Previously, a kinetic model of the perfused rat liver system was presented that included the… CONTINUE READING