Incorporation of photo-carbon monoxide releasing materials into electrospun scaffolds for vascular tissue engineering.

@article{Michael2016IncorporationOP,
  title={Incorporation of photo-carbon monoxide releasing materials into electrospun scaffolds for vascular tissue engineering.},
  author={E. Nowatkowski Michael and Nawodi Abeyrathna and Aatish V Patel and Yi Liao and Chris A Bashur},
  journal={Biomedical materials},
  year={2016},
  volume={11 2},
  pages={025009}
}
Hyper-proliferation of smooth muscle cells (SMCs) and a reduction in endothelial cell function are reasons for poor patency rates of current tissue engineered small-diameter vascular grafts. The controlled delivery of carbon monoxide (CO), a gasotransmitter involved in cell signaling, could improve vascular cell function in these grafts. Current CO releasing molecules (CORMs) can improve endothelialization of injured vessels with appropriate doses, but they still have limitations. The goal of… CONTINUE READING

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