Incorporation of molecular data into the Revised International Prognostic Scoring System in treated patients with myelodysplastic syndromes

@article{Nazha2016IncorporationOM,
  title={Incorporation of molecular data into the Revised International Prognostic Scoring System in treated patients with myelodysplastic syndromes},
  author={Aziz Nazha and Mayur Narkhede and Tomas Radivoyevitch and David J Seastone and Bhumika J. Patel and Aaron T Gerds and Sudipto Mukherjee and Matt E. Kalaycio and Anjali S. Advani and Bartlomiej Przychodzen and Hetty E. Carraway and Jaroslaw Maciejewski and Mikkael A. Sekeres},
  journal={Leukemia},
  year={2016},
  volume={30},
  pages={2214-2220}
}
The Revised International Prognostic Scoring System (IPSS-R) was developed for untreated myelodysplastic syndrome (MDS) patients based on clinical data. We created and validated a new model that incorporates mutational data to improve the predictive capacity of the IPSS-R in treated MDS patients. Clinical and mutational data from treated MDS patients diagnosed between January 2000 and January 2012 were used to develop the new prognostic system. A total of 508 patients were divided into training… CONTINUE READING