Incorporation of large amounts of gentamicin sulphate into acrylic bone cement: effect on handling and mechanical properties, antibiotic release, and biofilm formation.

@article{Dunne2008IncorporationOL,
  title={Incorporation of large amounts of gentamicin sulphate into acrylic bone cement: effect on handling and mechanical properties, antibiotic release, and biofilm formation.},
  author={Nicholas J. Dunne and Janet E. Hill and Patricia McAfee and Robert C. Kirkpatrick and S. A. Ciccia Patrick and Michael M. Tunney},
  journal={Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine},
  year={2008},
  volume={222 3},
  pages={
          355-65
        }
}
Bacterial infection remains a significant complication following total joint replacement. If infection is suspected when revision surgery is being performed, a large dose of antibiotic, usually gentamicin sulphate, is often blended with the acrylic bone cement powder in an attempt to reduce the risk of recurrent infection. In this in-vitro study the effect of small and large doses of gentamicin sulphate on the handling and mechanical properties of the cement, gentamicin release from the cement… CONTINUE READING

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