Incorporation of isotopically labeled cocaine and metabolites into human hair: 1. dose-response relationships.

@article{Henderson1996IncorporationOI,
  title={Incorporation of isotopically labeled cocaine and metabolites into human hair: 1. dose-response relationships.},
  author={Graeme B. Henderson and Martha R. Harkey and Chunxi Zhou and Reese Jones and Peyton Jacob},
  journal={Journal of analytical toxicology},
  year={1996},
  volume={20 1},
  pages={
          1-12
        }
}
Deuterium-labeled cocaine (cocaine-d5) was administered intravenously and/or intranasally in doses of 0.6-4.2 mg/kg to 25 human volunteers under laboratory clinical conditions. Sequential blood samples were collected for up to 3 days, and hair samples were collected for up to 10 months. Samples were analyzed by gas chromatography-mass spectrometry (GC-MS) for cocaine-d5 and its major metabolite, benzoylecgonine-d5 (BZE-d5). The parent drug, cocaine-d5, was the predominant analyte in hair… CONTINUE READING

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