Incorporation of influenza A virus genome segments does not absolutely require wild-type sequences.

@article{Fujii2009IncorporationOI,
  title={Incorporation of influenza A virus genome segments does not absolutely require wild-type sequences.},
  author={Ken Ichi Fujii and Makoto Ozawa and Kiyoko Iwatsuki-Horimoto and Taisuke Horimoto and Yoshihiro Kawaoka},
  journal={The Journal of general virology},
  year={2009},
  volume={90 Pt 7},
  pages={
          1734-40
        }
}
The efficient incorporation of influenza virus genome segments into virions is mediated by cis-acting regions at both ends of the viral RNAs. It was shown previously that nt 16-26 at the 3' end of the non-structural (NS) viral RNA of influenza A virus are important for efficient virion incorporation and that nt 27-56 also contribute to this process. To understand further the signalling requirements for genome packaging, this study performed linker-scanning mutagenesis in the latter region and… CONTINUE READING

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