Incorporation of glycosylphosphatidylinositol-anchored granulocyte- macrophage colony-stimulating factor or CD40 ligand enhances immunogenicity of chimeric simian immunodeficiency virus-like particles.

@article{Skountzou2007IncorporationOG,
  title={Incorporation of glycosylphosphatidylinositol-anchored granulocyte- macrophage colony-stimulating factor or CD40 ligand enhances immunogenicity of chimeric simian immunodeficiency virus-like particles.},
  author={Ioanna Skountzou and Fu-Shi Quan and Sailaja Gangadhara and L Ye and Andrei N. Vzorov and Periasamy Selvaraj and Joshy Jacob and Richard W. Compans and Sang-Moo Kang},
  journal={Journal of virology},
  year={2007},
  volume={81 3},
  pages={1083-94}
}
The rapid worldwide spread of human immunodeficiency virus (HIV) mandates the development of successful vaccination strategies. Since live attenuated HIV is not accepted as a vaccine due to safety concerns, virus-like particles (VLPs) offer an attractive safe alternative because they lack the viral genome yet they are perceived by the immune system as a virus particle. We hypothesized that adding immunostimulatory signals to VLPs would enhance their efficacy. To accomplish this we generated… CONTINUE READING

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