Incorporation of gene-specific variability improves expression analysis using high-density DNA microarrays

@article{Budhraja2003IncorporationOG,
  title={Incorporation of gene-specific variability improves expression analysis using high-density DNA microarrays},
  author={Vikram Budhraja and Edward L. Spitznagel and W Timothy Schaiff and Yoel Sadovsky},
  journal={BMC Biology},
  year={2003},
  volume={1},
  pages={1 - 1}
}
The assessment of data reproducibility is essential for application of microarray technology to exploration of biological pathways and disease states. Technical variability in data analysis largely depends on signal intensity. Within that context, the reproducibility of individual probe sets has not been hitherto addressed. We used an extraordinarily large replicate data set derived from human placental trophoblast to analyze probe-specific contribution to variability of gene expression. We… CONTINUE READING

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