Incorporation of different antibiotics into carbonated hydroxyapatite coatings on titanium implants, release and antibiotic efficacy.

@article{Stigter2004IncorporationOD,
  title={Incorporation of different antibiotics into carbonated hydroxyapatite coatings on titanium implants, release and antibiotic efficacy.},
  author={Martin Stigter and Jeff Bezemer and Klass de Groot and Pierre Layrolle},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2004},
  volume={99 1},
  pages={127-37}
}
Carbonated hydroxyapatite (CHA) coatings were applied onto titanium implants by using a biomimetic precipitation method. Different antibiotics were incorporated into the CHA coatings and their release and efficacy against bacteria growth were studied in vitro. The following antibiotics were used within this study: cephalothin, carbenicillin, amoxicillin, cefamandol, tobramycin, gentamicin and vancomycin. Increased concentrations of antibiotics in the coating solution led to a higher quantity of… CONTINUE READING