Incorporation of a laminin-derived peptide (SIKVAV) on polymer-modified adenovirus permits tumor-specific targeting via α6-integrins

@article{Stevenson2007IncorporationOA,
  title={Incorporation of a laminin-derived peptide (SIKVAV) on polymer-modified adenovirus permits tumor-specific targeting via α6-integrins},
  author={Mark M Stevenson and Arthur H. Hale and Samuel J M Hale and Nicola Green and Gregory P Black and Kerry David Fisher and Karel Ulbrich and {\'A}ngels Fabra and Leonard W Seymour},
  journal={Cancer Gene Therapy},
  year={2007},
  volume={14},
  pages={335-345}
}
Effective gene therapy for disseminated metastatic cancer is currently impossible because of poor delivery of vector to target sites. Modification of viral vectors to target advanced cancer has long been a challenge. In this study, we aimed to redirect adenovirus tropism to infect prostate cancer cells via α6β1 integrins, whose expression is upregulated during prostate cancer progression. To ablate normal mechanisms of infection and provide a framework for attachment of targeting ligands… CONTINUE READING

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