Incorporation of Mycobacterium tuberculosis lipoarabinomannan into macrophage membrane rafts is a prerequisite for the phagosomal maturation block.

@article{Welin2008IncorporationOM,
  title={Incorporation of Mycobacterium tuberculosis lipoarabinomannan into macrophage membrane rafts is a prerequisite for the phagosomal maturation block.},
  author={Amanda Welin and Martin E. Winberg and Hana Khidir Abdalla and Eva S{\"a}rndahl and Birgitta Rasmusson and Olle Stendahl and Maria Lerm},
  journal={Infection and immunity},
  year={2008},
  volume={76 7},
  pages={
          2882-7
        }
}
Lipoarabinomannan (LAM) is one of the key virulence factors for Mycobacterium tuberculosis, the etiological agent of tuberculosis. During uptake of mycobacteria, LAM interacts with the cell membrane of the host macrophage and can be detected throughout the cell upon infection. LAM can inhibit phagosomal maturation as well as induce a proinflammatory response in bystander cells. The aim of this study was to investigate how LAM exerts its action on human macrophages. We show that LAM is… CONTINUE READING
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