Incorporation of Eicosatrienoic Acid Exerts Mild Anti-inflammatory Properties in Murine RAW264.7 Cells

@article{Chen2014IncorporationOE,
  title={Incorporation of Eicosatrienoic Acid Exerts Mild Anti-inflammatory Properties in Murine RAW264.7 Cells},
  author={Szu-Jung Chen and Lu-Te Chuang and Sung-Nien Chen},
  journal={Inflammation},
  year={2014},
  volume={38},
  pages={534-545}
}
Eicosatrienoic acid (Δ11,14,17-20:3; ETrA) is a rare naturally occurring n-3 polyunsaturated fatty acid (PUFA). Using murine RAW264.7 cells, the objectives were to determine how ETrA modulated phospholipid fatty acid compositions and the production of pro-inflammatory mediators. Incubation cells with ETrA dose-dependently increased the proportions of phospholipid ETrA and its metabolites to 33 % of the fatty acid total. Incorporation of ETrA also reduced the proportions of total n-6 PUFA and… CONTINUE READING

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