Incorporation of 3-Aminobenzanthrone into 2′-Deoxyoligonucleotides and Its Impact on Duplex Stability

Abstract

3-Nitrobenzanthrone (3NBA), an environmental pollutant and potent mutagen, causes DNA damage via the reaction of its metabolically activated form with the exocyclic amino groups of purines and the C-8 position of guanine. The present work describes a synthetic approach to the preparation of oligomeric 2'-deoxyribonucleotides containing a 2-(2'-deoxyguanosin… (More)
DOI: 10.4061/2011/521035

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@inproceedings{Lukin2011IncorporationO3, title={Incorporation of 3-Aminobenzanthrone into 2′-Deoxyoligonucleotides and Its Impact on Duplex Stability}, author={Mark A. Lukin and Tanya Zaliznyak and Francis Johnson and Carlos R. de los Santos}, booktitle={Journal of nucleic acids}, year={2011} }