Incorporation and release of vancomycin from poly(D,L-lactide-co-glycolide) microspheres.

  title={Incorporation and release of vancomycin from poly(D,L-lactide-co-glycolide) microspheres.},
  author={Terence William Atkins and Sharon J Peacock and Debby J Yates},
  journal={Journal of microencapsulation},
  volume={15 1},
Spherical monolithic microspheres, with a honeycomb-like internal architecture, composed of PLCG 50:50 and PLCG 75:25 and containing a range of vancomycin loadings, have been fabricated using a W/O emulsification with solvent evaporation technique. Microspheres were generated in high yield (80 wgt%) and vancomycin incorporation, confirmed using the displacement of DSC thermograms, had no significant effect on microsphere size distribution (5-50 microns). The vancomycin encapsulation efficiency… CONTINUE READING

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