Incorporating pharmacokinetic differences between children and adults in assessing children's risks to environmental toxicants.

@article{Ginsberg2004IncorporatingPD,
  title={Incorporating pharmacokinetic differences between children and adults in assessing children's risks to environmental toxicants.},
  author={Gary L. Ginsberg and Dale B. Hattis and Babasaheb Sonawane},
  journal={Toxicology and applied pharmacology},
  year={2004},
  volume={198 2},
  pages={164-83}
}
Children's risks from environmental toxicant exposure can be affected by pharmacokinetic factors that affect the internal dose of parent chemical or active metabolite. There are numerous physiologic differences between neonates and adults that affect pharmacokinetics including size of lipid, and tissue compartments, organ blood flows, protein binding capacity, and immature function of renal and hepatic systems. These factors combine to decrease the clearance of many therapeutic drugs, which can… CONTINUE READING

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