Incorporating energy metabolism into a growth model of multicellular tumor spheroids.

  title={Incorporating energy metabolism into a growth model of multicellular tumor spheroids.},
  author={Raja Venkatasubramanian and Michael A. Henson and Neil S Forbes},
  journal={Journal of theoretical biology},
  volume={242 2},
Diffusion limitations in tumors create regions that are deficient in essential nutrients and contain a large number of quiescent and dying cells. Chemotherapeutic compounds are not effective against quiescent cells and therefore have reduced efficacy against tumors with extensive quiescence. We have formulated a mathematical model that predicts the extent and location of quiescence in multicellular spheroids. Multicellular spheroids are in vitro models of in vivo tumor growth that have proven… CONTINUE READING
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Biochemistry for the Medical Sciences

  • A. E. Newsholme, A. R. Leech
  • 1983
Highly Influential
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