Incorporating a guanidine-modified cytosine base into triplex-forming PNAs for the recognition of a C-G pyrimidine–purine inversion site of an RNA duplex

@inproceedings{Toh2016IncorporatingAG,
  title={Incorporating a guanidine-modified cytosine base into triplex-forming PNAs for the recognition of a C-G pyrimidine–purine inversion site of an RNA duplex},
  author={Desiree-Faye Kaixin Toh and G Nandhini Devi and Kiran M. Patil and Qiuyu Qu and Manikantha Maraswami and Yunyun Xiao and Teck Peng Loh and Yanli Zhao and Gang Chen},
  booktitle={Nucleic acids research},
  year={2016}
}
RNA duplex regions are often involved in tertiary interactions and protein binding and thus there is great potential in developing ligands that sequence-specifically bind to RNA duplexes. We have developed a convenient synthesis method for a modified peptide nucleic acid (PNA) monomer with a guanidine-modified 5-methyl cytosine base. We demonstrated by gel… CONTINUE READING