Incorporating Genetic Biomarkers into Predictive Models of Normal Tissue Toxicity.

@article{Barnett2015IncorporatingGB,
  title={Incorporating Genetic Biomarkers into Predictive Models of Normal Tissue Toxicity.},
  author={Gillian C. Barnett and Sarah Kerns and D J Noble and Alison M. Dunning and Catharine M. L. West and Neil G. Burnet},
  journal={Clinical oncology (Royal College of Radiologists (Great Britain))},
  year={2015},
  volume={27 10},
  pages={579-87}
}
There is considerable variation in the level of toxicity patients experience for a given dose of radiotherapy, which is associated with differences in underlying individual normal tissue radiosensitivity. A number of syndromes have a large effect on clinical radiosensitivity, but these are rare. Among non-syndromic patients, variation is less extreme, but equivalent to a ±20% variation in dose. Thus, if individual normal tissue radiosensitivity could be measured, it should be possible to… CONTINUE READING
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