Inconsistent blood brain barrier disruption by intraarterial mannitol in rabbits: implications for chemotherapy

@article{Joshi2010InconsistentBB,
  title={Inconsistent blood brain barrier disruption by intraarterial mannitol in rabbits: implications for chemotherapy},
  author={Shailendra Joshi and Aysegul Ergin and Mei Wang and Roberto Reif and Jane Zhang and Jeffrey N. Bruce and Irving J. Bigio},
  journal={Journal of Neuro-Oncology},
  year={2010},
  volume={104},
  pages={11-19}
}
The novel ability to quantify drug and tracer concentrations in vivo by optical means leads to the possibility of detecting and quantifying blood brain barrier (BBB) disruption in real-time by monitoring concentrations of chromophores such as Evan’s Blue. In this study, experiments were conducted to assess the disruption of the BBB, by intraarterial injection of mannitol, in New Zealand white rabbits. Surgical preparation included: tracheotomy for mechanical ventilation, femoral and selective… CONTINUE READING