Incomplete protection of hamsters vaccinated with unlipidated OspA from Borrelia burgdorferi infection is associated with low levels of antibody to an epitope defined by mAb LA-2.

@article{Johnson1995IncompletePO,
  title={Incomplete protection of hamsters vaccinated with unlipidated OspA from Borrelia burgdorferi infection is associated with low levels of antibody to an epitope defined by mAb LA-2.},
  author={Barbara J. B. Johnson and Steven L. Sviat and C. M. Happ and John J. Dunn and Jos{\'e} C Frantz and Leonard W. Mayer and Joseph F. Piesman},
  journal={Vaccine},
  year={1995},
  volume={13 12},
  pages={1086-94}
}
Efforts to develop a recombinant vaccine for Lyme disease have focused on using the outer surface protein A (OspA) of Borrelia burgdorferi as an immunogen. We evaluated the effectiveness of an unlipidated recombinant OspA as a vaccine in hamsters. This molecule is soluble and can be produced in high yield in Escherichia coli, characteristics that permit simple and relatively low cost production. Vaccination with unlipidated OspA protected a substantial portion of animals--59-79%, depending on… CONTINUE READING
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