Incomplete protection, but suppression of virus burden, elicited by subunit simian immunodeficiency virus vaccines.

@article{Israel1994IncompletePB,
  title={Incomplete protection, but suppression of virus burden, elicited by subunit simian immunodeficiency virus vaccines.},
  author={Zimra R Israel and P F Edmonson and Donald H. Maul and Shawn P O'neil and Sally P. Mossman and Clotilde Thiriart and Luc Fabry and Omer van Opstal and Claudine Bruck and Françoise Bex},
  journal={Journal of virology},
  year={1994},
  volume={68 3},
  pages={1843-53}
}
We compared the efficacy of immunization with either simian immunodeficiency virus (SIV) Env glycoprotein (Env), Env plus Gag proteins (Gag-Env), or whole inactivated virus (WIV), with or without recombinant live vaccinia vector (VV) priming, in protecting 23 rhesus macaques (six vaccine and two control groups) from challenge with SIVmac251 clone BK28. Vaccination elicited high titers of syncytium-inhibiting and anti-Env (gp120/gp160) antibodies in all vaccinated macaques and anti-Gag (p27… CONTINUE READING

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