Incomplete processing of progastrin expressed by human colon cancer cells: role of noncarboxyamidated gastrins.

@article{Singh1994IncompletePO,
  title={Incomplete processing of progastrin expressed by human colon cancer cells: role of noncarboxyamidated gastrins.},
  author={Pomila Singh and Zhao-Dong Xu and Bosong Dai and Srinivasan Rajaraman and Nancy R Rubin and B R Dhruva},
  journal={The American journal of physiology},
  year={1994},
  volume={266 3 Pt 1},
  pages={G459-68}
}
Gastrin is mitogenic for several colon cancers. To assess a possible autocrine role of gastrin in colon cancers, we examined human colon cancer cell lines for expression of gastrin mRNA and various forms of gastrin. Gastrin mRNA was not detected in the majority of colon cancer cell lines by Northern hybridization but was detected in all human colon cancer lines by the sensitive method of reverse transcriptase-polymerase chain reaction (PCR). Gastrin mRNA was quantitated by the competitive PCR… CONTINUE READING
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