Incomplete nonsense-mediated mRNA decay in Giardia lamblia.

  title={Incomplete nonsense-mediated mRNA decay in Giardia lamblia.},
  author={Yi-Hsiu Chen and Li-Hsin Su and Chin-Hung Sun},
  journal={International journal for parasitology},
  volume={38 11},
Messenger RNAs containing premature translation stop codons are degraded by a nonsense-mediated mRNA decay (NMD) system. The NMD pathway is present in yeast, plants and mammals and is thought to protect cells from production of nonfunctional proteins by rapidly degrading mutant mRNAs. There is little understanding of the biology of the origins of eukaryotes, particularly of the NMD pathway. Searches using the BLAST program revealed that the protozoan Giardialamblia has only some of the… CONTINUE READING
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