Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors

@inproceedings{Ducker2014IncompleteIO,
  title={Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors},
  author={Gregory S. Ducker and Chloe E Atreya and Jeffry P. Simko and Yun Kit Hom and Mary R. Matli and Cyril H Benes and Byron Hann and Eric K. Nakakura and Emily Bergsland and David B. Donner and Jeffrey Settleman and Kevan M. Shokat and Robert S. Warren},
  booktitle={Oncogene},
  year={2014}
}
The mammalian target of rapamycin (mTOR) regulates cell growth by integrating nutrient and growth factor signaling and is strongly implicated in cancer. But mTOR is not an oncogene, and which tumors will be resistant or sensitive to new adenosine triphosphate (ATP) competitive mTOR inhibitors now in clinical trials remains unknown. We screened a panel of over 600 human cancer cell lines to identify markers of resistance and sensitivity to the mTOR inhibitor PP242. RAS and phosphatidylinositol 3… CONTINUE READING
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