Incomplete beta-ketone processing as a mechanism for polyene structural variation in the FR-008/candicidin complex.

@article{Zhou2008IncompleteBP,
  title={Incomplete beta-ketone processing as a mechanism for polyene structural variation in the FR-008/candicidin complex.},
  author={Yongjun Zhou and Jialiang Li and Jing Zhu and Shi Chen and Linquan Bai and Xiufen Zhou and Houming Wu and Zixin Deng},
  journal={Chemistry & biology},
  year={2008},
  volume={15 6},
  pages={
          629-38
        }
}
FR-008/candicidin is a heptaene macrolide with established antifungal activity, produced by Streptomyces sp. FR-008 as a complex mixture of compounds. Here, six components (FR-008-I to -VI) of the FR-008/candicidin complex were determined; III, V, and VI were confirmed as natural products, principally differing from each other at C-3 and C-9, while the other three were believed to originate from the respective conversions of the natural ones in vitro. Inactivation of KR21 and DH18, respectively… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 10 CITATIONS

Enzymology of the polyenes pimaricin and candicidin biosynthesis.

  • Methods in enzymology
  • 2009
VIEW 6 EXCERPTS
CITES RESULTS & BACKGROUND
HIGHLY INFLUENCED

Tailoring the P450 monooxygenase gene for FR-008/candicidin biosynthesis.

  • Applied and environmental microbiology
  • 2009
VIEW 1 EXCERPT

References

Publications referenced by this paper.
SHOWING 1-10 OF 44 REFERENCES