Incomplete Reversibility of Estimated Glomerular Filtration Rate Decline Following Tenofovir Disoproxil Fumarate Exposure

  title={Incomplete Reversibility of Estimated Glomerular Filtration Rate Decline Following Tenofovir Disoproxil Fumarate Exposure},
  author={S. Stephen Jose and Lisa Hamzah and Lucy J. Campbell and Dorothea D M Nitsch and Rachael G Jones and Caroline Sabin and Frank A. Post and Jonathan Ainsworth and Jane Anderson and David R. Chadwick and Valerie Delpech and Martin Fisher and Brian George Gazzard and Richard Gilson and Mark Gompels and Margaret A T Johnson and Clifford S Leen and Mark Richard Nelson and Chloe M. Orkin and Adrian Palfreeman and Deenan Pillay and Achim Schwenk and John Walsh and Teresa A. Garrett Hill and Susie Huntington and Sophie Josie and A. Phillips and Alicia Thornton and Nigel Garrett and Johanne Lynch and Jack Hand and C. de Souza and Naomi Perry and Simon Tilbury and David Churchill and Menashe B. Waxman and David Asboe and Sundhiya Mandalia and Sajid Munshi and Hardik Korat and Miriam Poulton and Carolyn W. Taylor and Zachary Gleisner and Lee W. Campbell and Abdel Babiker and David T Dunn and A. J. Glabay and Nataliya Brima and Ian Williams and Carolyn Wood and Sinead Miller and Michael Youle and Fiona C Lampe and Cristian Smith and Hanna Grabowska and Chris Chaloner and Dewi Ismajani Puradiredja and Jill Weber and Farhan Ramzan and N. Mackie and A Thomas Winston and Anna Wilson and Sue Allan and Alisha Moore and Kerri Wakeman and Stephen Kegg and Paul Main and Mitchell and Hunter and Memory Sachikonye and Phillip Hay and Mandip Dhillon},
  booktitle={The Journal of infectious diseases},
BACKGROUND Tenofovir disoproxil fumarate (TDF) has been linked to renal impairment, but the extent to which this impairment is reversible is unclear. We aimed to investigate the reversibility of renal decline during TDF therapy. METHODS Cox proportional hazards models assessed factors associated with discontinuing TDF in those with an exposure duration of >6 months. In those who discontinued TDF therapy, linear piecewise regression models estimated glomerular filtration rate (eGFR) slopes… CONTINUE READING
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