Incomplete MyoD-induced transdifferentiation is associated with chromatin remodeling deficiencies

@inproceedings{Manandhar2017IncompleteMT,
  title={Incomplete MyoD-induced transdifferentiation is associated with chromatin remodeling deficiencies},
  author={Dinesh Manandhar and Lingyun Song and Ami Meda Kabadi and Jennifer B. Kwon and Lee E. Edsall and M. Ehrlich and Koji Tsumagari and Charles A Gersbach and Gregory E. Crawford and Raluca Gord{\^a}n},
  booktitle={Nucleic acids research},
  year={2017}
}
Our current understanding of cellular transdifferentiation systems is limited. It is oftentimes unknown, at a genome-wide scale, how much transdifferentiated cells differ quantitatively from both the starting cells and the target cells. Focusing on transdifferentiation of primary human skin fibroblasts by forced expression of myogenic transcription factor MyoD, we performed quantitative analyses of gene expression and chromatin accessibility profiles of transdifferentiated cells compared to… CONTINUE READING
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