Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells

@article{Ohi2011IncompleteDM,
  title={Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells},
  author={Yuki Ohi and Han Qin and Chibo Hong and Laure Blouin and Jose M Polo and Tingxia Guo and Zhongxia Qi and Sara L. Downey and Philip D. Manos and Derrick J Rossi and Jingwei Yu and Matthias Hebrok and Konrad Hochedlinger and Joseph F. Costello and Jun S. Song and Miguel Ramalho-Santos},
  journal={Nature Cell Biology},
  year={2011},
  volume={13},
  pages={541-549}
}
Human induced pluripotent stem (iPS) cells are remarkably similar to embryonic stem (ES) cells, but recent reports indicate that there may be important differences between them. We carried out a systematic comparison of human iPS cells generated from hepatocytes (representative of endoderm), skin fibroblasts (mesoderm) and melanocytes (ectoderm). All low-passage iPS cells analysed retain a transcriptional memory of the original cells. The persistent expression of somatic genes can be partially… CONTINUE READING
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