Incomplete, asymmetric, and route-dependent cross-tolerance between oxycodone and morphine in the Dark Agouti rat.

@article{Nielsen2000IncompleteAA,
  title={Incomplete, asymmetric, and route-dependent cross-tolerance between oxycodone and morphine in the Dark Agouti rat.},
  author={C. Kaergaard Nielsen and Fraser B Ross and Maree T Smith},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2000},
  volume={295 1},
  pages={91-9}
}
Our previous studies indicate that oxycodone is a putative kappa-opioid agonist, whereas morphine is a well documented micro-opioid agonist. Because there is limited information regarding the development of tolerance to oxycodone, this study was designed to 1) document the development of tolerance to the antinociceptive effects of chronically infused i.v. oxycodone relative to that for i. v. morphine and 2) quantify the degree of antinociceptive cross-tolerance between morphine and oxycodone in… CONTINUE READING

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