Inclusions of amyotrophic lateral sclerosis-linked superoxide dismutase in ventral horns, liver, and kidney.

@article{Jonsson2008InclusionsOA,
  title={Inclusions of amyotrophic lateral sclerosis-linked superoxide dismutase in ventral horns, liver, and kidney.},
  author={P Andreas Jonsson and Daniel Bergemalm and Peter Munch Andersen and Ole Gredal and Thomas Br{\"a}nnstr{\"o}m and Stefan L Marklund},
  journal={Annals of neurology},
  year={2008},
  volume={63 5},
  pages={671-5}
}
Mutant superoxide dismutases type 1 (SOD1s) cause amyotrophic lateral sclerosis by an unidentified toxic property. In a patient carrying the G127X truncation mutation, minute amounts of SOD1 were found in ventral horns using a mutant-specific antibody. Still, both absolute levels and ratios versus wild-type SOD1 were considerably greater than in other central nervous system areas and peripheral organs. Inclusions of mutant SOD1 were abundant in motoneurons but were also seen in hepatocytes and… CONTINUE READING

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