Inclusion of peripancreatic lymph node cells prevents recurrent autoimmune destruction of islet transplants: evidence of donor chimerism.

@article{Bartlett1995InclusionOP,
  title={Inclusion of peripancreatic lymph node cells prevents recurrent autoimmune destruction of islet transplants: evidence of donor chimerism.},
  author={Steven T Bartlett and Toinette Chin and B M Dirden and Absar Ahmed Quereshi and Gregg A. Hadley},
  journal={Surgery},
  year={1995},
  volume={118 2},
  pages={392-7; discussion 397-8}
}
BACKGROUND Recurrent autoimmune beta-cell destruction may contribute to the poor results of clinical islet transplantation. Pancreas transplants from diabetes-resistant BB rats (BB-DR) are uniformly successful in autoimmune diabetic BB rats (BB-Ac), but isolated islets are destroyed, despite immunosuppression. In this study we tested the hypothesis that whole pancreas transplants abrogate autoimmunity by passive transfer to the host of an autoregulatory T-cell subset. METHODS BB-Ac rats… CONTINUE READING

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