Inclusion of malignant fibrous histiocytoma in the tumour spectrum associated with hereditary non-polyposis colorectal cancer.

@article{Sijmons2000InclusionOM,
  title={Inclusion of malignant fibrous histiocytoma in the tumour spectrum associated with hereditary non-polyposis colorectal cancer.},
  author={Rolf Sijmons and Robert Hofstra and Harry Hollema and Ronald P Mensink and Annemariet van der Hout and Hans A. Hoekstra and Jan Kleibeuker and Willemina M. Molenaar and Juul Wijnen and Riccardo Fodde and Hans R.A. Vasen and C. H. Buys},
  journal={Genes, chromosomes & cancer},
  year={2000},
  volume={29 4},
  pages={353-5}
}
Sarcomas, including the malignant fibrous histiocytomas (MFHs), are not known to be part of the tumour spectrum of hereditary non-polyposis colorectal cancer (HNPCC) as epidemiologically established. Therefore, occurrence of MFH in an HNPCC family may very well be coincidental. HNPCC is associated with germline mutations in DNA mismatch repair genes, including the MSH2 gene. We analysed an MFH diagnosed in a 45-year-old male HNPCC patient carrying a germline MSH2 mutation for HNPCC-associated… CONTINUE READING

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