Inclusion body myositis and myopathies

  title={Inclusion body myositis and myopathies},
  author={Kumaraswamy Sivakumar and Marinos C. Dalakas},
  journal={Journal of the Neurological Sciences},
Sporadic inclusion body myositis and hereditary inclusion body myopathy.
An awareness of the clinical phenotype and of the electrodiagnostic and histopathologic features should lead to improved recognition, and should minimize confusion with polymyositis, motor neuron disease, and other neuromuscular disorders.
Familial Inclusion Body Myositis (FIBM): Update
The combination of clinical, histological, immunopathological and immunogenetic features indicates that these patients have a disease identical to sporadic inclusion body myositis.
Emerging therapeutic options for sporadic inclusion body myositis
This review discusses the clinical presentation of inclusion body myositis and the current efforts in diagnosis, and focuses on the current state of research for both nonpharmacological and pharmacological treatment options for this patient group.
Inclusion body myositis: genetic factors, aberrant protein expression, and autoimmunity
This review summarizes the new information on genetic factors, abnormal protein expression and inflammation, which provides a basis for linking the different typical morphologic features of s-IBM to a cascade of pathogenic events.
Inclusion body myositis: clinical review and current practice
The purpose of this review is to provide an update on the scientific developments in IBM with particular emphasis on current and future clinical trials.
While DM, PM and NM respond well to immunosuppressive treatment, IBM is usually resistant to immunotherapy and this review aims to give a concise overview and provide guidance for general management of myositis.
Myouclear Breakdown in Sporadic Inclusion Body Myositis
Figures that show abnormal localization of nuclear proteins associated with MAP kinase in s-IBM muscle fibers suggest that inhibition of nuclear transport during myogenesis is suggested and the theory that nuclear damage is closely associated with its etiology is supported.
Sporadic inclusion body myositis: the genetic contributions to the pathogenesis
This review summarizes the current understanding of the genetic contributions to sIBM and provides some insights for future research in this mysterious disease with the advantage of the rapid development of advanced genetic technology.
Oculopharyngeal myopathy with inflammation and calcinosis: an unusual phenotype
The case is reported of a patient with progressive proximal and distal weakness, dysphagia, respiratory weakness, calcifications, ptosis and ophthalmoparesis with inflammation, rimmed vacuoles and