Inclusion-body myositis

@article{Askanas2006InclusionbodyM,
  title={Inclusion-body myositis},
  author={Valerie Askanas and W. King Engel},
  journal={Neurology},
  year={2006},
  volume={66},
  pages={S39 - S48}
}
Sporadic inclusion-body myositis (s-IBM), the most common muscle disease of older persons, is of unknown cause and there is no successful treatment. We summarize our most recent findings, which provide a better understanding of the steps in the pathogenetic cascade. We suggest that s-IBM is primarily a myodegenerative disease. Intriguing are the phenotypic similarities between s-IBM muscle fibers and the brains of Alzheimer disease, the most common neurodegenerative disease of older persons. In… 

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TLDR
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TLDR
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TLDR
A brief overview of the validity of the various controversial observations is examined and the justification for the two major hypotheses for the primary role of inflammation versus degeneration are critically reviewed.
Mitochondrial Biology in Sporadic Inclusion Body Myositis
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The role of the mitochondria in the development of sIBM and the role of amyloid beta on mitochondrial function in skeletal muscle are evaluated to help to identify novel prevention and/ or treatment strategies.
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