Inclusion body myositis: Review of recent literature
@article{Greenberg2009InclusionBM, title={Inclusion body myositis: Review of recent literature}, author={Steven A. Greenberg}, journal={Current Neurology and Neuroscience Reports}, year={2009}, volume={9}, pages={83-89} }
Inclusion body myositis (IBM) is a progressive inflammatory skeletal muscle disease of unknown cause and without effective treatment. This article discusses existing literature, emphasizing disease mechanisms and models. In particular, it addresses limitations in the β-amyloid-mediated theory of IBM myofiber injury, flawed rationales of animal models of this disease, and recent reports regarding treatment.
32 Citations
Theories of the Pathogenesis of Inclusion Body Myositis
- Biology, MedicineCurrent rheumatology reports
- 2010
Specific theories of its pathogenesis are reviewed and general considerations pertaining to modeling of this disease discussed, and the critical role of biomarkers and methodologic issues in their discovery are considered.
Inclusion body myositis: old and new concepts
- MedicineJournal of Neurology, Neurosurgery & Psychiatry
- 2009
Inclusion body myositis (IBM) is the most common idiopathic inflammatory myopathy occurring in patients over the age of 50 years and probably accounts for about 30% of all inflammatory myopathies.…
Inclusion body myositis: therapeutic approaches.
- Medicine, BiologyDegenerative neurological and neuromuscular disease
- 2012
Various treatments that have been employed in IBM will be discussed even though none of the interventions has sufficient evidence to support its routine use, because IBM is a slowly progressive disease so assessment of treatment efficacy is problematic.
Evaluation and treatment of inflammatory myopathies
- MedicineJournal of Neurology, Neurosurgery & Psychiatry
- 2009
Greater understanding of the pathogenic bases of these disorders should hopefully lead to better treatment and well designed, prospective, double blind, placebo controlled trials are needed to determine the best therapeutic options for these different disorders.
Mitochondrial Biology in Sporadic Inclusion Body Myositis
- Biology, Medicine
- 2014
The role of the mitochondria in the development of sIBM and the role of amyloid beta on mitochondrial function in skeletal muscle are evaluated to help to identify novel prevention and/ or treatment strategies.
Amyloid deposits and inflammatory infiltrates in sporadic inclusion body myositis: the inflammatory egg comes before the degenerative chicken
- Biology, MedicineActa Neuropathologica
- 2015
It is imperative that neurologists and rheumatologists recognize this disorder which may, through clinical and pathological similarities, mimic other myopathies, especially polymyositis, which responds to immunosuppressant drug therapy poorly.
Vacuolar myopathy in a dog resembling human sporadic inclusion body myositis
- Biology, MedicineActa Neuropathologica
- 2009
Observations constitute the first evidence that both the inflammatory and degenerative features of human sIBM can occur in a non-human species.
Sporadic inclusion body myositis: possible pathogenesis inferred from biomarkers.
- Biology, MedicineCurrent opinion in neurology
- 2010
Therapies aimed at improving protein homeostasis, instead of targeting a specific protein that may or may not accumulate in all sIBM patients, could be useful future strategies for this devastating and enigmatic disorder.
Myopathy in a rhesus monkey with biopsy findings similar to human sporadic inclusion body myositis
- Biology, MedicineNeuromuscular Disorders
- 2013
Long-term observational study of sporadic inclusion body myositis.
- MedicineBrain : a journal of neurology
- 2011
It is confirmed that sporadic inclusion body myositis is slowly progressive but not lethal and that immunosuppressive treatments do not ameliorate its natural course, thus confirming findings from smaller studies.
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