Including robustness in multi-criteria optimization for intensity-modulated proton therapy.

  title={Including robustness in multi-criteria optimization for intensity-modulated proton therapy.},
  author={Wei Chen and Jan Unkelbach and Alexei Trofimov and Thomas J. Madden and Hanne Kooy and Thomas Bortfeld and David Craft},
  journal={Physics in medicine and biology},
  volume={57 3},
We present a method to include robustness in a multi-criteria optimization (MCO) framework for intensity-modulated proton therapy (IMPT). The approach allows one to simultaneously explore the trade-off between different objectives as well as the trade-off between robustness and nominal plan quality. In MCO, a database of plans each emphasizing different treatment planning objectives, is pre-computed to approximate the Pareto surface. An IMPT treatment plan that strikes the best balance between… CONTINUE READING


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