Inclisiran in Patients at High Cardiovascular Risk with Elevated LDL Cholesterol

@article{Ray2017InclisiranIP,
  title={Inclisiran in Patients at High Cardiovascular Risk with Elevated LDL Cholesterol},
  author={Kausik K. Ray and Ulf Landmesser and Lawrence A Leiter and David G. Kallend and Robert Dufour and Mahir Karakas and Tim Hall and Roland P.T. Troquay and Traci A Turner and Frank L. J. Visseren and Peter L. J. Wijngaard and R. Scott Wright and John J Kastelein},
  journal={The New England Journal of Medicine},
  year={2017},
  volume={376},
  pages={1430–1440}
}
BACKGROUND In a previous study, a single injection of inclisiran, a chemically synthesized small interfering RNA designed to target PCSK9 messenger RNA, was found to produce sustained reductions in low‐density lipoprotein (LDL) cholesterol levels over the course of 84 days in healthy volunteers. METHODS We conducted a phase 2, multicenter, double‐blind, placebo‐controlled, multiple‐ascending‐dose trial of inclisiran administered as a subcutaneous injection in patients at high risk for… 

Figures from this paper

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Inclisiran is a disruptive, first-in-class small interfering RNA (siRNA)-based therapeutic developed for the treatment of hypercholesterolemia that inhibits proprotein convertase subtilisin–kexin type 9 (PCSK9) synthesis, thereby upregulating the number of LDL receptors on the hepatocytes, thus lowering the plasma LDL-C concentration.

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The infrequent dosing regimen offers a major advantage to improve long term compliance and inclisiran may be extensively adopted depending on the cost.

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