Incidental pituitary uptake on whole-body 18F-FDG PET/CT: a multicentre study

@article{Jeong2010IncidentalPU,
  title={Incidental pituitary uptake on whole-body 18F-FDG PET/CT: a multicentre study},
  author={Shin Young Jeong and Sang-Woo Lee and Hui-Joong Lee and Sungmin Kang and Ji-Hyoung Seo and Kyung Ah Chun and Ihn Ho Cho and Kyung Sook Won and Seok Kil Zeon and Byeong-Cheol Ahn and Jaetae Lee},
  journal={European Journal of Nuclear Medicine and Molecular Imaging},
  year={2010},
  volume={37},
  pages={2334-2343}
}
PurposeThe purpose of this study was to determine the incidence of incidental pituitary uptake on whole-body 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) and to investigate its clinical significance.MethodsThe files of 40,967 patients who underwent whole-body FDG PET/CT were retrospectively reviewed. Quantification of pituitary metabolic activity was obtained by using the maximum standardized uptake value (SUVmax). Hormone assays and pituitary MRIs were… 

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A high SUVmax value is associated with an increased probability of pituitary incidentaloma and indicates that further imaging and hormonal evaluation are warranted in 18F-FDG PET-CT patients.

Incidental Focal 18F-FDG Uptake in the Pituitary Gland: Clinical Significance and Differential Diagnostic Criteria

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Although incidental pituitary uptake is an unusual finding, the degree of 18F-FDG accumulation is helpful in identifying pathologic pituitsary lesions that warrant further diagnostic evaluation.

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Prevalence and clinical significance of incidental 18F-FDG uptake in the pituitary

TLDR
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CRH stimulation improves 18F-FDG-PET detection of pituitary adenomas in Cushing’s disease

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This case demonstrates that the pituitary FDG uptake is related to the secretory pattern of the adenoma and not directly dependent of the tumour mass.
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