Incidental pituitary uptake on whole-body 18F-FDG PET/CT: a multicentre study

  title={Incidental pituitary uptake on whole-body 18F-FDG PET/CT: a multicentre study},
  author={Shin Young Jeong and Sang-Woo Lee and Hui-Joong Lee and Sungmin Kang and Ji-Hyoung Seo and Kyung Ah Chun and Ihn Ho Cho and Kyung Sook Won and Seok Kil Zeon and Byeong-Cheol Ahn and Jaetae Lee},
  journal={European Journal of Nuclear Medicine and Molecular Imaging},
PurposeThe purpose of this study was to determine the incidence of incidental pituitary uptake on whole-body 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) and to investigate its clinical significance.MethodsThe files of 40,967 patients who underwent whole-body FDG PET/CT were retrospectively reviewed. Quantification of pituitary metabolic activity was obtained by using the maximum standardized uptake value (SUVmax). Hormone assays and pituitary MRIs were… 

incidence and Clinical impact of Focal Pituitary Uptake in 18 F-Fluorodeoxyglucose Positron-emission tomography – Computed tomography : 5-Year Retrospective Review

A high SUVmax value is associated with an increased probability of pituitary incidentaloma and indicates that further imaging and hormonal evaluation are warranted in 18F-FDG PET-CT patients.

Incidental Focal 18F-FDG Uptake in the Pituitary Gland: Clinical Significance and Differential Diagnostic Criteria

Although incidental pituitary uptake is an unusual finding, the degree of 18F-FDG accumulation is helpful in identifying pathologic pituitsary lesions that warrant further diagnostic evaluation.

Incidental pituitary adenoma detected by 18F-FDG PET/CT and 18F-choline PET/CT in the same patient.

Analysis of 18F-fluorodeoxyglucose positron emission tomography findings in patients with pituitary lesions

About 80% of pituitary adenomas showed positivity on PET scans, and SUVmax was related to the size of theAdenomas, suggesting PET may be used as an ancillary tool for detection and differentiation ofpituitary lesions.

Pituitary 18F-FDG uptake correlates with serum TSH levels in thyroid cancer patients on 18F-FDG PET/CT

The study established the positive correlation between pituitary 18F-FDG uptake and serum TSH levels and confirmed that L-T4 replacement for DTC patients may well have the same feedback on the thyroid–pituitary axis as the physiologic thyroid status.

The clinical impact of incidental sellar uptake on F-18 FDG PET/CT

FDG accumulation in the sellar region might be associated with metastasis or adenoma, however, it did not change management and future studies are warranted.

Accumulation of 11C-methionine in the normal pituitary gland on 11C-methionine PET

PET/CT with 11C-methonine shows strong accumulation in normal pituitary gland, and would thus be feasible to differentiate between normal and abnormal pituitaries.

Prevalence and clinical significance of incidental 18F-FDG uptake in the pituitary

Clinicians, radiologists and nuclear medicine physicians should be aware that incidental 18F-FDG uptake in the pituitary is an infrequent finding corresponding to benign lesions in most of the cases, Nevertheless, if the patient has normal life expectancy, MRI pituitsary examination should be performed to better characterize these incidental findings due to possible clinical consequences of some pituitarian incidentalomas if untreated.

CRH stimulation improves 18F-FDG-PET detection of pituitary adenomas in Cushing’s disease

The results of the current study suggest that oCRH-stimulation may lead to increased 18F-FDG uptake, and increased rate of detection of corticotropinomas in CD, and suggest that some MRI invisible adenomas may be detectable by oCRh-stimulated FDG-PET imaging.

Evolution of 18FDG pituitary uptake after medical control of acromegaly

This case demonstrates that the pituitary FDG uptake is related to the secretory pattern of the adenoma and not directly dependent of the tumour mass.



FDG-PET and CT characterization of adrenal lesions in cancer patients

PET accurately characterized Adrenal lesions and was most useful in the 52.5% of cancer patients with inconclusive adrenal lesions on CT, while visual interpretation was as accurate as SUV.

Clinical Significance of Diffusely Increased 18F-FDG Uptake in the Thyroid Gland

The incidental finding of increased 18F-FDG uptake in the thyroid gland is associated with chronic lymphocytic (Hashimoto's) thyroiditis and does not seem to be affected by thyroid hormone therapy.

Evaluation of thyroid FDG uptake incidentally identified on FDG-PET/CT imaging

More data are needed to elucidate the role of SUV in the differentiation of benign and malignant lesions and to characterize the prevalence and malignancy of thyroid 18F-flurodeoxyglucose uptake incidentally identified on FDG-PET/computed tomography (CT) scan in a relatively large population.

Incidental thyroid lesions detected by FDG-PET/CT: prevalence and risk of thyroid cancer

The results of this study suggest that incidentally found thyroid lesions by FDG-PET/CT, especially a focal FDG uptake and a high SUV, have a high risk of thyroid malignancy.

The diagnostic value of fused positron emission tomography/computed tomography in the localization of adrenocorticotropin-secreting pituitary adenoma in Cushing’s disease

PET-CT is positive in around 60% of the cases of CD, and if these findings are confirmed in larger studies, PET-CT might become an important diagnostic technique, especially when the more invasive and technically demanding procedure of IPSS is not available or inconclusive.

Is 18F-FDG PET/CT useful for imaging and management of patients with suspected occult recurrence of cancer?

  • O. IsraelM. Mor R. Epelbaum
  • Medicine
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • 2004
It is indicated that PET/CT may improve the accuracy of occult cancer detection and further lead to management changes in patients with increasing levels of tumor markers as the sole suspicion of recurrent malignancy.

Positron emission tomography of pituitary macroadenomas: hormone production and effects of therapies.

Positron emission tomography offers the potential capability for predicting and defining the growth of pituitary adenomas, and may be of particular value when plasma hormone assays and conventional imaging techniques prove inadequate for monitoring patient response to therapy.

Combined PET/CT Imaging in Oncology. Impact on Patient Management.

FDG PET detection of unknown primary tumors.

FDG PET is a valuable diagnostic tool in patients with cancer of unknown primary because it imaged unknown primary tumors in about one third of all patients investigated.

Pituitary Adenoma Detected on FDG Positron Emission Tomography in a Patient with Mucosa-Associated Lymphoid Tissue Lymphoma

This case provides evidence for avid uptake of FDG on PET imaging of pituitary adenomas in women with a history of treated non-Hodgkin’s lymphoma.