Incidental detection of Sertoli–Leydig cell tumor by FDG PET/CT imaging in a patient with androgen insensitivity syndrome

@article{zlker2010IncidentalDO,
  title={Incidental detection of Sertoli–Leydig cell tumor by FDG PET/CT imaging in a patient with androgen insensitivity syndrome},
  author={Tamer {\"O}z{\"u}lker and Tevfik {\"O}zpaçacı and Filiz {\"O}z{\"u}lker and {\"U}mit {\"O}zekici and Remziye Bilgiç and Meral Mert},
  journal={Annals of Nuclear Medicine},
  year={2010},
  volume={24},
  pages={35-39}
}
A 29-year-old female patient who was being followed up for differentiated papillary thyroid carcinoma was referred to us for exploration of any possible metastasis since her serum thyroglobulin levels were high. The patient underwent an F-18 fluorodeoxyglucose positron emission tomography study, and a pathologically increased FDG uptake at the left lower abdomen was detected corresponding to a solid, cystic lesion on CT images. The patient had a history of primary amenorrhea and, together with… 
View on Springer
ncbi.nlm.nih.gov
17 Citations
Background Citations
7

17 Citations

FDG PET/CT Image of Seminoma in Androgen Insensitivity Syndrome.

We report the FDG PET/CT findings of seminoma in a 21-year-old woman with androgen insensitivity syndrome. PET images showed focal FDG uptake in the left pelvic sidewall, and a hypodense lesion with…

Management of metastatic ovarian Sertoli-Leydig cell tumor with sporadic multinodular goiter: a case report and literature review.

TLDR
A young woman with stage IA, poorly differentiated SLCT who had a dramatic response to the combination of bleomycin, etoposide and cisplatin followed by stem cell transplantation and surgery, and has shown no evidence of disease recurrence for 8 months postoperatively.

Virilizing Leydig-Sertoli Cell Ovarian Tumor Associated with Endometrioid Carcinoma of the Endometrium in a Postmenopausal Patient: Case Report and General Considerations

TLDR
SLCT should be suspected in postmenopausal women who present rapid progressive androgen excess symptoms with hyperandrogenemia, especially in women in menopause with progressive signs of virilization.

Sertoli-Leydig Cell Tumor

TLDR
In this study three distinct SLCT cases, a well-differentiated, of intermediate differentiation and that with a retiform component were reported, emphasizing their differential diagnoses.

Bilateral Sertoli-Leydig cell tumor in a patient with complete androgen insensitivity syndrome: a case report and brief review of the literature

TLDR
The case of a 40-year-old woman with primary amenorrhea and infertility problems who presented to the doctor after discovering two pelvic tumors was reported and the diagnosis was complete androgen insensitivity syndrome with bilateral SertoliLeydig cell tumor, based on the clinical features, histology exams and genetic result.

Intussusception incidentally detected by FDG-PET/CT in a pediatric lymphoma patient

TLDR
An FDG-PET/CT scan was performed in a 14-year-old boy for the purpose of staging known lymphoma and found the intussusception caused by the lymphoma, which changed the management regime of the patient.

Bilateral Laparoscopic Gonadectomy in a Patient With Complete Androgen Insensitivity Syndrome and Bilateral Sertoli-Leydig Cell Tumor: A Case Report and Brief Review of the Literature

TLDR
A 28-year-old woman with complete (severe) androgen resistance underwent prophylactic laparoscopic bilateral gonadectomy and microscopic examination revealed bilateral well differentiated sertoli–leydig cell tumor (SLCT) in androgen insensitivity syndrome.

A Review of Radiologic Imaging in Patients withAndrogen Insensitivity

TLDR
A review of Radiologic Imaging in Patients with Androgen Insensitivity is a disorder of sex development that results from mutations in the androgen receptor.

Ovarian and Testicular Sex Cord-Stromal Tumors

TLDR
Testicular stromal tumors often behave in a benign fashion but can be aggressive depending upon age and histopathologic diagnosis; tumor markers play an important role in follow-up evaluations and should be obtained preoperatively when feasible.

Positron Emission Tomography/Computed Tomography for Gynecologic Malignancies

TLDR
Positron emission tomography/Computed tomography is clinically valuable for a variety of gynecologic cancers and plays an important role in detection of initial disease and recurrence of Gynecologic malignancies.

References

SHOWING 1-10 OF 19 REFERENCES

PET Imaging of Sertoli Cell Tumor in Androgen Insensitivity Syndrome

  • B. Nguyen
  • Medicine
    Clinical nuclear medicine
  • 2003
TLDR
This rare sex cord stromal tumor arose from the right gonad of a patient with a history of androgen insufficiency syndrome, also known as testicular feminization syndrome, during imaging workup for suspected right-lung malignant neoplasm.

Leydig cell tumor in an elderly patient with complete androgen insensitivity syndrome.

FDG PET for detection and therapy control of metastatic germ cell tumor.

TLDR
PET using FDG is superior to CT for assessment of residual tumor after chemotherapy of germ cell cancer and may have an increased effect on patient management in the future.

Ovarian sertoli-leydig cell tumors

TLDR
Results and a study of published data suggest that Sertoli-Leydig cell tumors arise from ovarian stroma, and because of their obvious morphological similarities to testicular structures they should be termed “gonadal stromal tumors of android type”.

Sertoli-Leydig cell tumor of the ovary: a clinicopathologic study of 10 cases.

TLDR
Ten patients with Sertoli-Leydig cell tumors of the ovary treated consecutively were analyzed retrospectively for clinicopathological characteristics, treatment modalities and survival, finding conservative surgery seems to be the treatment of choice in younger patients.

Sertoli-Leydig cell tumor of the ovary, a rare cause of precocious puberty in a 12-month-old infant.

TLDR
A 12-month-old infant who presented with a 4-month history of isosexual precocious puberty secondary to an estrogenizing Sertoli-Leydig cell tumor of the ovary is reported, the youngest reported occurrence of this rare sex cord stromal neoplasm.

The Androgen Insensitivity Syndrome (Testicular Feminization): A Clinicopathologic Study of 43 Cases

  • J. RutgersR. Scully
  • Medicine
    International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • 1991
TLDR
Forty-three patients with the androgen insensitivity syndrome (AIS), ages 14 to 83 (average 27) years, were studied and immature tubules were revealed, which contained rare spermatogonia in 28% of the cases.

Ovarian Sertoli-Leydig cell tumors. A clinicopathological analysis of 207 cases.

ABSTRACTThe clinical and pathological features of 207 ovarian Sertoli-Leydig cell tumors from our consultation and hospital files were reviewed. The patients ranged in age from 2 to 75 (average 25)…

Primary amenorrhea in a young Polish woman with complete androgen insensitivity syndrome and Sertoli–Leydig cell tumor: Identification of a new androgen receptor gene mutation and evidence of aromatase hyperactivity and apoptosis dysregulation within the tumor

  • K. JarząbekP. Philibert C. Sultan
  • Medicine, Biology
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • 2007
TLDR
It is suggested that the high expression of aromatase and other molecular changes in the testis may be responsible for pubertal breast development and the increased risk of testicular tumor.

Testicular development in the complete androgen insensitivity syndrome

TLDR
The risk of premalignant change in germ cells is low before and during puberty, and patients can be advised that gonadectomy can be delayed to allow for a natural puberty, with low risk of malignant transformation.