Incidental detection of Sertoli–Leydig cell tumor by FDG PET/CT imaging in a patient with androgen insensitivity syndrome

@article{zlker2010IncidentalDO,
  title={Incidental detection of Sertoli–Leydig cell tumor by FDG PET/CT imaging in a patient with androgen insensitivity syndrome},
  author={Tamer {\"O}z{\"u}lker and Tevfik {\"O}zpaçacı and Filiz {\"O}z{\"u}lker and {\"U}mit {\"O}zekici and Remziye Bilgiç and Meral Mert},
  journal={Annals of Nuclear Medicine},
  year={2010},
  volume={24},
  pages={35-39}
}
A 29-year-old female patient who was being followed up for differentiated papillary thyroid carcinoma was referred to us for exploration of any possible metastasis since her serum thyroglobulin levels were high. The patient underwent an F-18 fluorodeoxyglucose positron emission tomography study, and a pathologically increased FDG uptake at the left lower abdomen was detected corresponding to a solid, cystic lesion on CT images. The patient had a history of primary amenorrhea and, together with… 

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TLDR
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TLDR
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TLDR
The case of a 40-year-old woman with primary amenorrhea and infertility problems who presented to the doctor after discovering two pelvic tumors was reported and the diagnosis was complete androgen insensitivity syndrome with bilateral SertoliLeydig cell tumor, based on the clinical features, histology exams and genetic result.

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TLDR
An FDG-PET/CT scan was performed in a 14-year-old boy for the purpose of staging known lymphoma and found the intussusception caused by the lymphoma, which changed the management regime of the patient.

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TLDR
A 28-year-old woman with complete (severe) androgen resistance underwent prophylactic laparoscopic bilateral gonadectomy and microscopic examination revealed bilateral well differentiated sertoli–leydig cell tumor (SLCT) in androgen insensitivity syndrome.

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A review of Radiologic Imaging in Patients with Androgen Insensitivity is a disorder of sex development that results from mutations in the androgen receptor.

Ovarian and Testicular Sex Cord-Stromal Tumors

TLDR
Testicular stromal tumors often behave in a benign fashion but can be aggressive depending upon age and histopathologic diagnosis; tumor markers play an important role in follow-up evaluations and should be obtained preoperatively when feasible.

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This rare sex cord stromal tumor arose from the right gonad of a patient with a history of androgen insufficiency syndrome, also known as testicular feminization syndrome, during imaging workup for suspected right-lung malignant neoplasm.

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Results and a study of published data suggest that Sertoli-Leydig cell tumors arise from ovarian stroma, and because of their obvious morphological similarities to testicular structures they should be termed “gonadal stromal tumors of android type”.

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