Incidence of venous thromboembolism in first-degree relatives of patients with venous thromboembolism who have factor V Leiden.

@article{Couturaud2006IncidenceOV,
  title={Incidence of venous thromboembolism in first-degree relatives of patients with venous thromboembolism who have factor V Leiden.},
  author={Francis Couturaud and Clive Kearon and Christophe Leroyer and Bernard Mercier and Jean François Abgrall and Gregoire Le Gal and Karine Lacut and Emmanuel Oger and Luc Bressollette and Claude F{\'e}rec and Michel Lamure and Dominique Mottier},
  journal={Thrombosis and haemostasis},
  year={2006},
  volume={96 6},
  pages={744-9}
}
The factor V Leiden (FVL) mutation, a genetic abnormality with an autosomal mode of inheritance, is associated with an increased risk of venous thromboembolism (VTE). We aimed to determine the annual incidence of VTE in first-degree relatives of patients with VTE and FVL and to identify factors in patients and the relatives that influence this incidence. In this retrospective and prospective cohort study, the incidence of objectively diagnosed first episodes of VTE was assessed in 553 first… CONTINUE READING

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