Incidence of venous thromboembolism in families with inherited thrombophilia.

  title={Incidence of venous thromboembolism in families with inherited thrombophilia.},
  author={Paolo Simioni and B J Sanson and Paolo Prandoni and Daniela Tormene and Philip W. Friederich and Bruno Girolami and Sabrina Gavasso and Menno V. Huisman and Harry Roger B{\"u}ller and J Wouter ten Cate and Antonio Girolami and Martin H. Prins},
  journal={Thrombosis and haemostasis},
  volume={81 2},
The risk of spontaneous or risk-period related venous thromboembolism in family members of symptomatic carriers of antithrombin (AT), protein C (PC) or protein S (PS) defects, as well as of the Factor V Leiden mutation is still undefined. We performed a retrospective cohort study in family members (n = 793) of unselected patients with a documented venous thromboembolism and one of these deficiencies to make an estimate of this risk. The annual incidences of total and spontaneous venous… CONTINUE READING


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Familial thrombophilia. A review analysis

  • AGM van den Belt, MH Prins, MV Huisman, J. Hirsh
  • Clin Appl Thromb Hemost
  • 1996
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