Incidence of three cross-reactive idiotypes on human rheumatoid factor paraproteins.

@article{Crowley1988IncidenceOT,
  title={Incidence of three cross-reactive idiotypes on human rheumatoid factor paraproteins.},
  author={Joseph J. Crowley and R D Goldfien and Ralph E. Schrohenloher and Hans L. Spiegelberg and Gregg J Silverman and Rizgar A Mageed and Royston Jefferis and William J. Koopman and Dennis Anthony Carson and Shemian Fong},
  journal={Journal of immunology},
  year={1988},
  volume={140 10},
  pages={3411-8}
}
The basis for rheumatoid factor (RF) production in autoimmune or lymphoproliferative diseases cannot be understood without defining the molecular factors that dictate RF structure and specificity. Recently three different mAb (6B6.6, 17.109, and G6) have been developed that define cross-reactive idiotypes (CRI) on intact L or H chains of human monoclonal RF cryoglobulins. However, the true incidence of these CRI among RF and their relationship to each other have not been delineated. In the… CONTINUE READING