Incidence of sexually transmitted infections before and after preexposure prophylaxis for HIV

  title={Incidence of sexually transmitted infections before and after preexposure prophylaxis for HIV},
  author={Vinh-Kim Nguyen and Zo{\"e} R. Greenwald and Helen Trottier and Martha Cadieux and Alexandre Goyette and Mari{\`e}ve Beauchemin and Louise Charest and Dani{\`e}le Longpr{\'e} and St{\'e}phane Lavoie and Hermione Gbego Tossa and R{\'e}jean Thomas},
  journal={AIDS (London, England)},
  pages={523 - 530}
Objective: Use of preexposure prophylaxis (PrEP) for HIV raises concerns about sexually transmitted infection (STI) incidence because of decreased condom use among MSM. This study examines whether PrEP is associated with STIs in the 12 months following PrEP prescription relative to the 12 months prior to PrEP and if STI rates are higher among PrEP users relative to individuals receiving postexposure prophylaxis (PEP). Design: Retrospective cohort study including PrEP users with more than 12… 

Incidence and risk factors for recurrent sexually transmitted infections among MSM on HIV pre-exposure prophylaxis

STI incidence was high and increased over time and most STIs were concentrated in a high-risk group that should be targeted for future interventions.

Sexually Transmitted Infection Testing and Prevalence Before and After Preexposure Prophylaxis Initiation Among Men Aged ≥18 Years in US Private Settings

High STI prevalence before and after PrEP initiation in this study suggests that patients taking PrEP have an increased risk of acquiring STI.

Association of HIV Preexposure Prophylaxis With Incidence of Sexually Transmitted Infections Among Individuals at High Risk of HIV Infection

Among gay and bisexual men using PrEP, STIs were highly concentrated among a subset, and receipt of PrEP after study enrollment was associated with an increased incidence of STIs compared with preenrollment, highlighting the importance of frequent STI testing.

Concerns about a study on sexually transmitted infections after initiation of HIV preexposure prophylaxis.

Concerns are raised about this study, particularly with respect to study design and the degree to which the results support the conclusions of Nguyen et al.

HIV Pre-Exposure Prophylaxis and Increased Incidence of Sexually Transmitted Infections in the United States.

The implementation and utilization of HIV PrEP in the U.S. were associated with increased rates of STIs and further studies to confirm this association and to elucidate potential causes are needed.

Chemsex and incidence of sexually transmitted infections among Canadian pre-exposure prophylaxis (PrEP) users in the l’Actuel PrEP Cohort (2013–2020)

The high STI incidence among gbMSM who report chemsex highlights the importance of PrEP for this population and the need for integrated services that address the complexities of sexualised substance use.

HIV pre-exposure prophylaxis and sexually transmitted infections: intersection and opportunity

The successes and challenges of pre-exposure prophylaxis to date, its place as part of robust strategies to reduce HIV infections, the rising rates of curable sexually transmitted diseases and their relationship with HIV prevention, and future directions for synergies in PrEP and sexually transmitted disease prevention are discussed.

Sexually transmitted infections among participants in an HIV PrEP adherence trial

It was found that the incidence of STIs was not significantly different between those adherent to PrEP and those non-adherent, and further research is needed to assess how PrEP use may impact STIs over time.

Assessment for sexually transmitted infections in men who have sex with men attending a nurse-run HIV preexposure prophylaxis clinic

  • J. Stockton
  • Medicine
    Journal of the American Association of Nurse Practitioners
  • 2021
Sexually transmitted infection results in this population are consistent with those reported in other PrEP centers and reinforce importance of three-point chlamydia/gonorrhea testing as part of comprehensive STI evaluation.

Low use of condom and high STI incidence among men who have sex with men in PrEP programs

The incidence of STI acquisition was higher than expected, indicating a need for strategies to minimize this impact, particularly among younger individuals with a higher number of sexual partners.



Preexposure Prophylaxis for HIV Infection Integrated With Municipal- and Community-Based Sexual Health Services.

The incidence of HIV acquisition was extremely low despite a high incidence of STIs in a large US PrEP demonstration project, and adherence was higher among those participants who reported more risk behaviors.

LB1.4 Sti rates among gay men taking daily antiretrovirals for pre-exposure prophylaxis of hiv: the nsw demonstration project prelude

The baseline prevalence and incidence of STIs were high and remained high in the early follow-up (indeed, the incidence of gonorrhoea has increased) and the investigation of prophylaxis against other STIs and other methods of testing and treating STIs among these high-risk men appears to be warranted.

Pre-exposure prophylaxis for HIV infection and new sexually transmitted infections among men who have sex with men

A meta-analysis to summarize rates of sexually transmitted infections among men who have sex with men (MSM) on pre-exposure prophylaxis (PrEP) for HIV versus MSM not using PrEP showed that MSM using Pr EP were 25.3 times more likely to acquire a Neisseria gonorrhoeae infection.

Pre-exposure Prophylaxis (PrEP) Use, Seroadaptation, and Sexual Behavior Among Men Who Have Sex with Men, San Francisco, 2004–2014

Examination of trends in PrEP use, numbers of condomless anal sex partners, consistent condom use, and seroadaptive strategies in San Francisco finds that public health officials need to be realistic about the possibility that condom use could very well continue to decline as PrEPUse increases, and to an extent that may not be directly or indirectly offset by PrEP.

HIV Incidence Among Men Who Have Sex With Men After Diagnosis With Sexually Transmitted Infections

Men who have sex with men diagnosed as having rectal gonorrhea and early syphilis were at the greatest risk for being diagnosed asHaving HIV infection after STI diagnosis, and should be prioritized for more intensive prevention interventions, including PrEP.

Pre-Exposure Prophylaxis to Prevent HIV Infection: Current Status, Future Opportunities and Challenges

It is hoped that antiretroviral chemoprophylactic agents and delivery systems could become an acceptable, feasible, and highly effective addition to existing HIV prevention strategies.

On-Demand Preexposure Prophylaxis in Men at High Risk for HIV-1 Infection.

The use of TDF-FTC before and after sexual activity provided protection against HIV-1 infection in men who have sex with men, and the treatment was associated with increased rates of gastrointestinal and renal adverse events.

MSM starting preexposure prophylaxis are at risk of hepatitis C virus infection.

Routine HCV testing should be offered to MSM at high risk for HIV, especially for those enrolling in PrEP programs, because the increasing overlap between sexual networks of HIV-positive and HIV-negative MSM might result in an expanding HCV-epidemic irrespective of HIV status.

Preexposure Prophylaxis for HIV Prevention in a Large Integrated Health Care System: Adherence, Renal Safety, and Discontinuation

PrEP adherence was high in clinical practice, consistent with the lack of HIV seroconversions during PrEP use, and strategies are needed to increase PrEP access during gaps in insurance coverage.