Incidence of resistance in a double-blind study comparing lopinavir/ritonavir plus stavudine and lamivudine to nelfinavir plus stavudine and lamivudine.

@article{Kempf2004IncidenceOR,
  title={Incidence of resistance in a double-blind study comparing lopinavir/ritonavir plus stavudine and lamivudine to nelfinavir plus stavudine and lamivudine.},
  author={D. Kempf and M. King and B. Bernstein and P. Cernohous and E. Bauer and J. Moseley and K. Gu and A. Hsu and S. Brun and E. Sun},
  journal={The Journal of infectious diseases},
  year={2004},
  volume={189 1},
  pages={
          51-60
        }
}
  • D. Kempf, M. King, +7 authors E. Sun
  • Published 2004
  • Medicine
  • The Journal of infectious diseases
  • Study M98-863 was a double-blind, randomized, phase 3 study that compared lopinavir/ritonavir with nelfinavir, each coadministered with stavudine and lamivudine, in 653 antiretroviral therapy-naive human immunodeficiency virus (HIV) type 1-infected subjects. The incidence of HIV drug resistance was analyzed using baseline and rebound virus isolates from subjects with plasma HIV RNA >400 copies/mL from weeks 24 to 108 of therapy. No evidence of genotypic or phenotypic resistance to lopinavir… CONTINUE READING
    219 Citations
    Failure of treatment with first-line lopinavir boosted with ritonavir can be explained by novel resistance pathways with protease mutation 76V.
    • 39
    • PDF
    Impact of lopinavir/ritonavir use on antiretroviral resistance in recent clinical practice.
    • 5
    • PDF
    Efficacy and Tolerability of a Nucleoside Reverse Transcriptase Inhibitor-Sparing Combination of Lopinavir/Ritonavir and Efavirenz in HIV-1-Infected Patients
    • 34

    References

    SHOWING 1-10 OF 38 REFERENCES
    Lopinavir-ritonavir versus nelfinavir for the initial treatment of HIV infection.
    • 652
    Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavir.
    • 396
    • PDF
    Nelfinavir: an update on its use in HIV infection.
    • 115