Incidence of renal failure and nephroprotection by RAAS inhibition in heterozygous carriers of X-chromosomal and autosomal recessive Alport mutations.

Abstract

We studied here the clinical course of heterozygous carriers of X-linked Alport syndrome and a subgroup of patients with thin basement membrane disease due to heterozygous autosomal recessive Alport mutations whose prognosis may be worse than formerly thought. We analyzed 234 Alport carriers, including 29 with autosomal recessive mutations. Using Kaplan… (More)
DOI: 10.1038/ki.2011.452

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@article{Temme2012IncidenceOR, title={Incidence of renal failure and nephroprotection by RAAS inhibition in heterozygous carriers of X-chromosomal and autosomal recessive Alport mutations.}, author={Johanna Temme and Frederick Peters and Katharina Lange and Y. Yves Pirson and Laurence Heidet and Roser Torr{\'a} and J. -P. Grunfeld and Manfred Weber and Christoph Licht and Gerhard A. M{\"u}ller and Oliver A. Gross}, journal={Kidney international}, year={2012}, volume={81 8}, pages={779-83} }